The primary hypothesis of this study is that hypertonic saline is more effective than mannitol in the management of raised Intra-Cranial Pressure after severe Traumatic Brain Injury. The SoS trial will compare both using clinical outcomes and cost-effectiveness.
SoS
Sugar or Salt (SOS) Trial: Hyperosmolar therapy in traumatic brain injury
Background/method
Chief investigator
Chief investigator
Professor Gavin Perkins
Principal investigator
Principal investigator
Dr Nick Murphy
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