Tonny is a consultant in neurointensive care medicine and an honorary senior lecturer in the University of Birmingham clinical trials unit. His main research interests are mechanisms of brain injury and recovery after an acute insult (such as head injury).
- Research Scholar – Birmingham clinical trials unit
- Consultant in Critical Care Medicine (Neurocritical and general critical care) – Birmingham University Hospitals NHS Foundation Trust
- Honorary Senior Research Fellow – University of Birmingham
- Senior Faculty Tutor Final year medical students – University of Birmingham
Basic sciences and organ cross-talk after acute severe traumatic brain injury:
My research has fundamentally contributed to the understanding of the temporal profile of neuro-inflammation, acute physiology, proteomic, metabolomic and epigenomics after traumatic brain injury. This research also aims to investigate the serum (serum, cerebrospinal fluid and salivary markers including inflammatory, cytokine and next-generation sequencing), imaging (quantitative analysis of MRI, Computed tomography of brain and Positron Emission Tomography of the brain) and neurophysiological (electroencephalography) biomarkers after an acute head injury.
Collaborators: Professor A Belli, Professor A Logan, Professor Fang Gao Smith and Professor David Menon)
(a). QEHB charities (Chief Investigator – £ 0.125 million)
(b). Wellcome Trust (Co-applicant – £0 .24 million)
(c). NIAA (research train fellowship – £ 0.125Million)
Clinical trials after acute severe traumatic brain injury:
My research aims to understand the therapeutic options and modulation of the secondary damage after acute traumatic brain injury.
Collaborators: Professor Belli, Professor Logan, Professor G Perkins and Professor David Menon
(a). Co-Investigator (OSMOTIC, EME trial, 2019) invited for EME stage 2 application (£0.35 million)
(b). 2018 Co-Chief Investigator for NIHR Health technology assessment (HTA, NIHR, Salt or sugar (SoS) trial after traumatic brain injury) grant, co-chief investigator (£1.6 million)
(c). Midlands Neurotrauma research consortium (£10,000)
Health services research
This programme fundamentally aims to understand the optimal service delivery pattern in acute care within emergency medicine and critical care units within the UK.
Collaborators: Professor J Bion, Dr T Whitehouse and Professor Fang Gao –Smith
(a). Epilepsy Research UK (£ 9,000)
(b). Local critical care research funding (UoB and UHB) (£6,000)
Other acute and emergency medicine clinical trials:
This programme aims to understand and improve the outcomes of patients admitted acutely through the emergency, acute and critical care medicine. This research aims to study common cross-cutting presentations such pain (e.g. pain after multiple rib fractures, sepsis and ventilatory support) in the critical care unit with a focus on the survivorship.
Collaborators: Professor Fang Gao Smith and Professor J Bion
(a). Chief investigator, NIHR, stage one completed awaiting outcome (£2.4 million)
(b). Queen Elizabeth Charity (£20,000)
List of Publications
Queen Elizabeth Hospital Birmingham and University of Birmingham
My research programme was established in 2014, supporting the NIHR SRMRC`s strategic priority of understanding the brain in physiological and pathological states. Our focus has been on understanding the way the brain responds to injury and the reparative processes. This is achieved by a good mixture of basic sciences research and advanced clinical trials. Across our research programme, we aim to understand the dynamic impact of acute brain injury modulation or enhancement of recovery with various neurotherapeutic options. Tonny would accept PhD and MD students.