Improving the metrics for assessment of injury burden to improve patient stratification

Early interventions and patient stratification of the trauma patients is an important aspect in the area of trauma research.

Milestone n:0%

What does each milestone mean?

1 = Clinical need
2 = Idea
3 = Proof of concept
4 = Proof of feasibility
5 = Proof of value
6 = Initial clinical trials
7 = Validation of solution
8 = Approval and launch
9 = Clinical use
10 = Standard of care

Aim

Our aims are:

To integrate multi-modal data from physiological, biochemical and metabolomics datasets into a single framework and apply a variety of classical statistics as well as AI-based approaches to develop stratification and outcome predictions models.
Improve current Injury severity scoring systems using physiological measures for major trauma.
Identification of biomarkers that can assist actionable decision in the case of pre-hospital trauma.

Lay Summary

Early interventions and patient stratification of the trauma patients is an important aspect in the area of trauma research. We are developing a computational framework that integrates multiple different data sets and identify potential biomarkers for these patients. The biomarkers offer the potential of improved patient stratification as well as patient treatment and outcomes.

Background

Current Injury severity scoring systems initially developed to predict mortality in blunt trauma and then refined to predict all major trauma, are currently understood as having severe limitations in terms of both prediction as well as stratification of major trauma. In addition to that, integration of the multimodal data set a problem due to complex interactions of the inflammation and response to trauma. Our aim is to find a strategy to integrate multiple diverse data sets that can be used as physiological based scoring systems to stratify trauma patients and predict clinical outcomes into the rehabilitation phase of treatment.

Method

Using existing longitudinal physiological, metabolomics, and biochemical data from the SIRS, SIFTI and Golden Hour studies a repertoire of computational biology and systems biology techniques are applied to develop a model of injury that enables the improved stratification of patients. Artificial Intelligence based approaches are applied to cater for the integration of multimodal datasets, from metabolomics to clinical, so as to develop state of the art models from outcome prediction.